- Title
- A road map for the treatment of pediatric diffuse midline glioma
- Creator
- Koschmann, Carl; Al-Holou, Wajd N.; Clausen, Madison; Dang, Derek; Doherty, Robert; Duchatel, Ryan; Dun, Matthew; Filbin, Mariella; Franson, Andrea; Galban, Stefanie; Garcia Moure, Marc; Garton, Hugh; Alonso, Marta M.; Gowda, Pruthvi; Marques, JG; Hawkins, C; Heath, A; Hulleman, E; Ji, S; Jones, C; Kilburn, L; Kline, C; Koldobskiy, MA; Anastas, Jamie; Lim, D; Lowenstein, PR; Lu, QR; Lum, J; Mack, S; Magge, S; Marini, B; Martin, D; Marupudi, N; Messinger, D; Bandopadhayay, Pratiti; Mody, R; Morgan, M; Mota, M; Muraszko, K; Mueller, S; Natarajan, SK; Nazarian, J; Niculcea, M; Nuechterlein, N; Okada, H; Barron, Tara; Opipari, V; Pai, MP; Pal, S; Peterson, E; Phoenix, T; Prensner, JR; Pun, M; Raju, GP; Reitman, ZJ; Resnick, A; Becher, Oren; Rogawski, D; Saratsis, A; Sbergio, SG; Souweidane, M; Stafford, JM; Tzaridis, T; Venkataraman, S; Vittorio, O; Wadden, J; Wahl, D; Cartaxo, Rodrigo; Wechsler-Reya, RJ; Yadav, VN; Zhang, X; Zhang, Q; Venneti, S; Castro, Maria G.; Chung, Chan
- Relation
- Cancer Cell Vol. 42, Issue 1, p. 1-5
- Publisher Link
- http://dx.doi.org/10.1016/j.ccell.2023.11.002
- Publisher
- Cell Press
- Resource Type
- journal article
- Date
- 2024
- Description
- Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.
- Subject
- diffuse midline gliomas (DMGs); roadmap; diagnostics; pediatric
- Identifier
- http://hdl.handle.net/1959.13/1494774
- Identifier
- uon:53880
- Identifier
- ISSN:1535-6108
- Language
- eng
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